LABOTEST-BB LT00134672
antazoline hydrochloride
CAS: 2508-72-7
Molecular Formula: C17H20ClN3
LABOTEST-BB LT00134672 - Names and Identifiers
| Name | antazoline hydrochloride |
| Synonyms | ANTAZOLINE HCL Antazoline HCL LABOTEST-BB LT00134672 antazoline hydrochloride Phenazoline hydrochloride 2-(N-PHENYL-N-BENZYL-AMINOMETHYL)-IMIDAZOLINE HCL 2-(N-BENZYLANILINOMETHYL) IMIDAZOLINE HYDROCHLORIDE 2-Phenyl-benzyl-amino-methylimidazolin hydrochloride 2-(N-BENZYLANILINOMETHYL)-2-IMIDAZOLINE HYDROCHLORIDE N-Benzyl-N-(2-imidazolin-2-ylmethy)aniline hydrochloride BENZYL-(4,5-DIHYDRO-1H-IMIDAZOL-2-YLMETHYL)-PHENYL-AMINE HCL 2-{[benzyl(phenyl)amino]methyl}-4,5-dihydro-1H-imidazol-3-ium |
| CAS | 2508-72-7 |
| EINECS | 219-719-8 |
| InChI | InChI=1/C17H19N3/c1-3-7-15(8-4-1)13-20(14-17-18-11-12-19-17)16-9-5-2-6-10-16/h1-10H,11-14H2,(H,18,19)/p+1 |
LABOTEST-BB LT00134672 - Physico-chemical Properties
| Molecular Formula | C17H20ClN3 |
| Molar Mass | 301.81 |
| Melting Point | 238 °C |
| Boling Point | 475.5°C at 760 mmHg |
| Flash Point | 241.4°C |
| Solubility | Soluble in water (100 mM), alcohol (40 mg/ml), methanol, and ethanol (50 mg/ml). Insolu |
| Vapor Presure | 3.31E-09mmHg at 25°C |
| Appearance | Powder |
| Color | White to Off-White |
| Merck | 14,680 |
| Storage Condition | Inert atmosphere,Room Temperature |
| MDL | MFCD00058145 |
| Use | Anti-cholamine, with anticholinergic and local anesthetic effects, can be used for anti-allergic and anti-arrhythmic |
LABOTEST-BB LT00134672 - Risk and Safety
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| RTECS | NJ2150000 |
LABOTEST-BB LT00134672 - Standard
Authoritative Data Verified Data
This product is 4, 5-dihydro-n-phenyl-1-benzyl-1-imidazole-2-methylamine hydrochloride. The content of C17H19N3 • HCl shall not be less than 98.0% calculated on a dry basis.
Last Update：2024-01-02 23:10:35
LABOTEST-BB LT00134672 - Trait
Authoritative Data Verified Data
- This product is white or off-white crystalline powder; Odorless or almost odorless.
- This product is soluble in ethanol, slightly soluble in water, slightly soluble in chloroform, and almost insoluble in ether.
Last Update：2022-01-01 15:04:15
LABOTEST-BB LT00134672 - Differential diagnosis
Authoritative Data Verified Data
- take about 50mg of this product, add 5ml of water and 0.5ml of nitric acid, which is initially Red and gradually dark green.
- take this product, add 0.1 mol/ L hydrochloric acid solution was dissolved and diluted to prepare a solution containing about 20ug per 1 ml, which was determined by UV-Vis spectrophotometry (General 0401), there is a maximum absorption at the wavelength of 241NM and 29lnm.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 3 4 8).
- the aqueous solution of this product was chloride identification (1) of the reaction (General 0301).
Last Update：2022-01-01 15:04:15
LABOTEST-BB LT00134672 - Exam
Authoritative Data Verified Data
acidity
take this product l.Og, add water 100ml to dissolve, according to the law (General 0631),pH value should be 5.0~6.5.
Related substances
take this product, add mobile phase to dissolve and dilute to make about 0.1 mg of the solution was used as a test solution, and an appropriate amount was quantitatively diluted with a mobile phase to prepare a solution containing 1% per 1 ml as a control solution. According to the test of high performance liquid chromatography (General 0512), silica gel bonded with eighteen alkyl silane was used as the filler, and 0.02mol/L ammonium acetate solution (adjusted to pH 3.5 with glacial acetic acid)-methanol (57:43) as mobile phase, the detection wavelength was 242nm. The number of theoretical plates shall not be less than 5000 based on the calculation of the antazoline peak, and the separation degree between the antazoline peak and the adjacent impurity peak shall meet the requirements. 20ul of the test solution and the control solution were respectively injected into the human liquid chromatograph, and the chromatogram was recorded to 2 times of the retention time of the main component peak. If there are impurity peaks in the chromatogram of the test solution, the sum of each impurity peak area shall not be greater than the main peak area of the control solution (1.0%).
loss on drying
take this product, dry to constant weight at 105°C, weight loss shall not exceed 1.0% (General rule 0831).
ignition residue
take l.Og of this product and check it according to law (General rule 0841). The residue left shall not exceed 0.1%.
Heavy metals
The residue left under the item of taking the ignition residue shall not contain more than 20 parts per million of heavy metal when examined by law (General rule 0821, Law II).
Last Update：2022-01-01 15:04:16
LABOTEST-BB LT00134672 - Content determination
Authoritative Data Verified Data
take this product about 0.2g, precision weighing, add glacial acetic acid 20ml, add mercury acetate test solution 5ml, according to the potential titration method (General rule 0701), with perchloric acid titration solution (0.1 mol/L) titration, and the results of the titration were corrected with a blank test. Each 1 ml of perchloric acid titration solution (0.1 mol/L) corresponds to 30.18mg of C17H19N3. Hc1.
Last Update：2022-01-01 15:04:16
LABOTEST-BB LT00134672 - Category
Authoritative Data Verified Data
antihistamines.
Last Update：2022-01-01 15:04:16
LABOTEST-BB LT00134672 - Storage
Authoritative Data Verified Data
light shielding, sealed storage.
Last Update：2022-01-01 15:04:17
LABOTEST-BB LT00134672 - Anazoline hydrochloride tablets
Authoritative Data Verified Data
This product contains antazoline hydrochloride (C17H19N3 • HCI) should be 93.0% ~ 107.0% of the label amount.
trait
This product is white tablet.
identification
- take an appropriate amount of the fine powder of this product (about 50mg of antazoline hydrochloride), add 5ml of water, shake to dissolve the antazoline hydrochloride, add 1 ml of sodium hydroxide solution, shake, and extract with 25ml of chloroform, the residue was dissolved with 0.2ml of hydrochloric acid, added with 5ml of water and 0.5ml of nitric acid, which was initially Red and gradually dark green.
- the sample solution under the content measurement item was taken and measured by ultraviolet-visible spectrophotometry (General 0401), and the maximum absorption was found at wavelengths of 241nm and 291nm.
- Take appropriate amount of fine powder of this product, add water, shake, filter, filtrate chloride to identify (1) reaction (General rule 0301).
examination
- Related substances take fine powder of this product, add appropriate amount of mobile phase, shake to dissolve amoxazoline hydrochloride and dilute it with mobile phase to make about 0.1 mg of the solution was filtered, and the continued filtrate was taken as the test solution. An appropriate amount was taken in a precise amount, and the solution was quantitatively diluted with the mobile phase to prepare a solution containing 1 ml of amoxazoline hydrochloride lug per 1 ml, and used as a control solution. The test was carried out according to the method for related substances of anazoline hydrochloride. If there are impurity peaks in the chromatogram of the test solution, the sum of each impurity peak area shall not be greater than the main peak area of the control solution (1.0%).
- the dissolution of this product, according to the dissolution and release determination method (General rule 0931 second method), water 900ml as the dissolution medium, the speed of 50 rpm, according to the law, after 30 minutes, take the appropriate amount of solution, filter, take the appropriate amount of filtrate, dilute quantitatively with water to make a solution containing about 10% of antazoline hydrochloride in each lml, shake well, according to UV-visible spectrophotometry (General rule 0401 ), the absorbance was measured at the wavelength of 241nm, water was added to dissolve and quantitatively diluted to prepare a solution containing about 10ug per 1 ml, which was determined by the same method, and the dissolution amount of each tablet was calculated. The limit is 75% of the labeled amount and shall be in accordance with the provisions.
- others shall be in accordance with the relevant provisions under the item of tablets (General rule 0101).
Content determination
Take 20 tablets of this product, precision weighing, fine grinding, precision weighing an appropriate amount (equivalent to 0.lg of tarazoline hydrochloride), put it in a 200ml measuring flask, add 0.1 mol/L hydrochloric acid solution about 160ml, shake, warm to dissolve the antazoline hydrochloride, cool, with 0. Dilute 1 mol/L hydrochloric acid solution to the scale, shake well, filter, take 2ml of continuous filtrate accurately, put it in a 100ml measuring flask, use 0. Dilute 1 mol/L hydrochloric acid solution to the scale, shake well, as the test solution, according to UV-visible spectrophotometry (General 0401), at the wavelength of 241nm absorbance; separately take the reference product of antazoline hydrochloride, precision weighing, add 0.lmol/L hydrochloric acid solution is dissolved and quantitatively diluted to make a solution containing about 10ug per lml, which is determined and calculated by the same method.
category
The same as that of antazoline hydrochloride.
specification
O.lg
storage
light shielding, sealed storage.
Last Update：2022-01-01 15:04:17
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